Joe, I've got an '05 F150 with the 4.6L, and getting a check engine light code = misfire #3 cylinder. Mine has almost 130k, original spark plugs. (Not skipping, just getting the code.) New set of plugs (E3) in the garage, but I heard to horror stories too! (Plugs breaking off in the head, something about two piece spark plugs being used originally.) They're also a bugger to get at, the fuel rail runs right (and tight) over the top of the coils on top of the plugs. I'm a stickler for routine maintenance, and have never neglected anything this long. (Always do my own maintenance and repairs.) But darn it, this one has me a little concerned (okay scared), don't wanna disable my daily driver in the driveway, OR ruin a cylinder head.
Think I'm going to eventually soak them with PB Blaster and take a day off during the week to do the job, in case I have to call in a professional for "back up"?